In general, if you already have X5 on your PC, installing X6 will upgrade the X5 installation. In most cases you do not have to explicitly uninstall X5.
However, there have been a few cases where this hasn’t worked smoothly. If you find you have both X5 and X6 on your PC and they interfere, ICTS have now provided an option to uninstall X5.
If you go to the Programs and Features part of Control Panel, then click on the left-banner link ‘Install a program from the network’, you will find an additional entry:
Thompson Reuters Endnote X5.01 – Endnote Uninstall which should let you remove Endnote X5.
This should remove X5 for you.
Peter K